Chapters:

Chapter 1. Introduction

1.1 Defining Interoception

1.2 Measuring interoception in humans

1.3 Pathological interoception

1.4 interoceptive neurobiology

1.5 Goals of this dissertation

Chapter 2. Bridging the translational gap: Comparative insights into insula structure and function (published manuscript soon!)

2.1 Abstract

2.2 Introduction

2.3 What we mean by homology and why it matters

2.3 Structure and function of the insula in humans

2.4 The structure and function of the insula in monkeys

2.5 The structure of the insula in rodent species (relative to primates)

2.6 The function of the insula in rodent species (relative to primates)

Chapter 3. Intrinsic functional and structural networks of the macaque insula exhibit close homology with human insula (published version)

3.1 Abstract

3.2 Introduction

3.3 Materials and methods

3.4 Results

3.5 Discussion

3.6 Supplementary tables and figures

Chapter 4. Rhesus monkeys have an interoceptive sense of their beating hearts (published version)

4.1 Abstract

4.2 Introduction

4.3 Materials and methods

4.4 Results

4.5 Discussion

4.6 Supplementary figures

Chapter 5. Evolutionarily conserved neural responses to affective touch in monkeys transcend consciousness and change with age (published version)

5.1 Abstract

5.2 Introduction

5.3 Materials and methods

5.4 Results

5.5 Discussion

5.6 Supplementary figures

Chapter 6. General discussion and future discussions

6.1 Summary of the findings

6.2 Implications of evolutionary conserved interoception

6.3 Interoception in monkey models of disease

6.4 The insula, interoception, and aging

6.5 Concluding remarks